Table 3.
Effect of E2 on Cortical Bone Composition in POMC-ERα−/− Mice
| Control |
POMC-ERα−/− |
|||
|---|---|---|---|---|
| OVX | OVX + E2 | OVX | OVX + E2 | |
| μCT | ||||
| Cortical vBMD (mg/cm3) | 1319 ± 12 | 1317 ± 11 | 1318 ± 13 | 1300 ± 12 |
| FTIR | ||||
| Mineral to matrix ratio | 1.36 ± 0.09 | 1.66 ± 0.14 | 1.46 ± 0.13 | 1.66 ± 0.22 |
| Collagen maturity | 0.21 ± 0.02 | 0.19 ± 0.01 | 0.24 ± 0.07 | 0.20 ± 0.02 |
| Crystallinity | 0.078 ± 0.004 | 0.081 ± 0.004 | 0.080 ± 0.006 | 0.082 ± 0.003 |
μCT (femur; n = 7–10) and FTIR microspectroscopy (humerus; n = 4–7) analyses of cortical bone from OVX POMC-ERα−/− and OVX control mice treated with either E2 (0.5 μg/d) or vehicle. Data are presented as mean ± SEM.