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Serum levels of P1NP (filled bars), a marker of bone formation, and type I collagen CtX (open bars), a marker of bone resorption, were increased significantly after 2 weeks of PTH treatment in TG mice. Cre induction via tamoxifen had no effect on P1NP levels, but CtX levels were significantly increased by βcat deletion. Asterisks indicate significant (P < .05) PTH-induced difference from the tam/oil-matched vehicle control, using PLSD post hoc pairwise tests.
