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Plasma ghrelin and leptin levels. Fast plasma ghrelin (A) and random-fed leptin (B) levels determined at the experimental outset (before high-fat diet [HFD] feeding), and 4 or 9 months after HFD feeding. Results are mean ± SEM (n = 9–10); *, P < .05; **, P < .01; ***, P < .001 vs wild-type control.
