Table 1.
Serum Parameters in Wild-Type, BChE KO, and AAV-BChE-treated BChE KO Mice
| Wild Type | BChE KO | BChE KO + AAV-BChE | |
|---|---|---|---|
| BChE (U/mL) | 1.16 ± 0.04 | 0c | 38.36 ± 5.0c |
| Leptin (ng/mL) | 45 ± 5 | 73 ± 8a | 45 ± 9 |
| Total cholesterol (mg/mL) | 0.78 ± 0.24 | 1.47 ± 0.16a | 0.66 ± 0.19 |
| LDL/VLDL (mg/mL) | 0.13 ± 0.01 | 0.21 ± 0.02c | 0.19 ± 0.03 |
| Fast insulin (ng/mL) | 0.54 ± 0.04 | 0.97 ± 0.15b | 0.88 ± 0.38a |
| Fast IGF-1 (ng/mL) | 541 ± 34 | 656 ± 34a | 639 ± 25a |
| Fast ghrelin (pg/mL) | 372 ± 38 | 222 ± 25b | 327 ± 71 |
| Fast desacyl-ghrelin (pg/mL) | 713 ± 94 | 349 ± 37b | 870 ± 186 |
| Blood glucose (mg/dL) | 167 ± 7 | 165 ± 10 | 174 ± 11 |
| Fast blood glucose (mg/dL) | 87 ± 11 | 91 ± 6 | 86 ± 10 |
Circulating concentrations were measured in 10-month-old mice after 9 months of high-fat feeding (9–10 animals per group). Results are mean ± SEM. Statistical significance was assessed by 2-tailed Student's t tests.
a
P < .05 vs wild-type control.
b
P < .01 vs wild-type control.
c
P < .001 vs wild-type control.