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Schematic representation of the main cellular pathways involved in the generation of nuclear, cytosolic, and mitochondrial acetyl-CoA for lipid biosynthesis and protein acetylation. Mal-CoA, malonyl-CoA; FA, fatty acid; FA-CoA, fatty acid-CoA; AAs, amino acids; Cit, citrate; OAA, oxaloacetate; Ac-carn, acetyl-carnitine; PDC, pyruvate dehydrogenase complex.
