Table 2.
20-HETE and ω-hydroxylase activities in cerebral and renal vessels and renal microsomes of control and hyperandrogenemic (DHT-treated) SD female rats
| 20-HETE Level, pmol/mg |
ω-Hydroxylase Activity, pmol 20-HETE·min−1·mg−1 |
|||||
|---|---|---|---|---|---|---|
| Cerebral Vessels | Renal Vessels | Renal Microsomes | Cerebral Vessels | Renal Vessels | Renal Microsomes | |
| Control rats | 0.51 ± 0.04 | 0.15 ± 0.02 | 1.25 ± 0.0 | 0.62 ± 0.03 | 0.20 ± 0.04 | 119.06 ± 4.9 |
| DHT-treated rats | 0.51 ± 0.06 | 0.81 ± 0.08 | Below detection | 0.09 ± 0.02 | 0.69 ± 0.14 | 101.15 ± 3.4 |
| P value | NS | <0.0001 | <0.0001 | <0.0001 | <0.009 | <0.01 |
n = 6 rats/group. 20-HETE, 20-hydroxyeicosatetraenoic acid; NS, not significant.