Table 4.
SS.5Bn |
CYP4A2−/− |
|||
---|---|---|---|---|
Control | DHT | Control | DHT | |
Body weight, g | 269 ± 3 | 358 ± 11* | 254 ± 9‡ | 384 ± 13*†‡ |
DHT, pg/ml | 27.29 ± 2.50 | 110.88 ± 5.67* | 27.30 ± 2.68†‡ | 101.82 ± 10.74*† |
Estradiol, pg/ml | 9.54 ± 1.64 | 3.91 ± 0.85* | 6.92 ± 0.73‡ | 4.40 ± 0.50*† |
n = 6–8 rats/group. CYP, cytochrome P-450.
P < 0.05 compared with controls of the same strain;
P < 0.05 compared with control SS.5Bn rats;
P < 0.05 compared with DHT-treated SS.5Bn rats.