Table 1.

Histopathological criteria used to differentiate various stages in progression of HCC

	Hepatic Adenoma (HA)	Dysplastic Nodule (DN)	Well-Differentiated Hepatocellular Carcinoma (HCC)
Hepatocytes	Normal	Dysplastic	Dysplastic
N:C ratio	Normal	Increased	Increased
Nuclear hyperchromasia	Absent	Present	Present
Mitotic figures	Absent	Few	Frequent
Plate width	1–2 Cells	2–3 Cells thick	>3 Cells thick
Reticulin	Intact	Focally disrupted	Markedly disrupted or absent
Absence of portal tracts	+	±	+
Sinusoidal capillarization (CD34)	±	±	+

N:C ratio, nuclear-to-cytoplasmic ratio.