Table 2.

Global gene expression changes in promotion of DEN-induced liver tumors by 0.2% cholic acid

Group Comparison	Upregulated genes	Downregulated Genes
0.2% CA vs. ND	20	20
DEN + ND vs. ND	335	28
DEN + 0.2% CA vs. ND	569	130
DEN + 0.2% CA vs. 0.2% CA	310	59
DEN + 0.2% CA vs. DEN + ND	18	17

Global gene expression changes are number of genes that changed (up or down) more than 3-fold.

CA, cholic acid; ND, normal diet; DEN, diethylnitrosamine.