Table 3.
Upstream regulators activated and inhibited in DEN +0.2% CA group
| Upstream Regulator | Predicted Activation State | Activation z-Score | P Value of Overlap |
|---|---|---|---|
| Transcription Factors | |||
| NFκB | Activated | 2.792 | 1.38E-04 |
| NUPR1 | Activated | 2.558 | 7.10E-05 |
| NANOG | Activated | 2.236 | 4.73E-02 |
| RBPJ | Inhibited | −2.000 | 2.49E-02 |
| Estrogen receptor | Inhibited | −2.111 | 1.31E-01 |
| NR3C1 | Inhibited | −2.219 | 5.26E-02 |
| SREBF1 | Inhibited | −2.592 | 5.81E-06 |
| Cytokines and Growth Factors | |||
| IFNγ | Activated | 3.240 | 9.10E-05 |
| IL1β | Activated | 3.068 | 3.54E-06 |
| TNFα | Activated | 2.846 | 7.98E-06 |
| IFNα2 | Activated | 2.570 | 1.09E-05 |
| IL1α | Activated | 2.447 | 2.73E-03 |
| CSF2 | Activated | 2.236 | 1.94E-01 |
| IFNL1 | Activated | 2.138 | 8.11E-04 |
| IL1RN | Inhibited | −2.345 | 5.82E-04 |