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. 2016 May 5;311(1):G32–G39. doi: 10.1152/ajpgi.00067.2016

Fig. 5.

Fig. 5.

GHS rats exhibited anxiety-like behavior in the elevated plus maze, social interaction, and cold stress tests relative to controls. A: bar graph showing the average times spent on the closed and open arms of the elevated plus maze by control, control + HeICS, GHS, and GHS + HeICS rats. GHS rats spent significantly less time in the open arm of the elevated plus maze compared with controls. HeICS significantly reduced the open arm time of control rats but was without significant effect on the open arm time in GHS rats (*P < 0.05; 2-way ANOVA, n = 12 each). B: bar graph showing the average number of entries in the open and closed arms. GHS, control + HeICS, and GHS + HeICS rats made significantly fewer open arm entries compared with controls (*P < 0.05; 2-way ANOVA, n = 12 each). C: bar graph showing no significant differences in the average total distance traveled in meters (m) on the elevated plus maze (P > 0.05; 2-way ANOVA, n = 12 each). D: bar graphs showing a significant increase in the number of fecal pellets defecated in response to cold stress in GHS rats compared with controls (*P < 0.05, n = 12 each; t-test). E: bar graphs showing a significant decline in time spent in social interaction by GHS rats compared with controls (*P < 0.05, n = 12 each; t-test).