Fig. 2.
Absolute pressure-volume loops (A), overall hysteresis, i.e., the volume of each pressure-volume loop reflecting the work of breathing (B), and pressure-volume loops expressed relative to total lung volume (C) in 2 (●, continuous line)-, 6 (○, dashed line)-, 18 (■, dotted line)-, 24 (□, dashed-dotted line)-, and 30 (▲, gray continuous line)-mo-old mice. Data were analyzed via a two-way ANOVA (A and C) and a one-way ANOVA (B) with Tukey's HSD post hoc test. *P < 0.05, 2 mo vs. 6, 18, 24, and 30 mo; †P < 0.05, 6 mo vs. 18, 24, and 30 mo; ‡P < 0.05, 18 mo vs. 24 and 30 mo; §P < 0.05, 24 mo vs. 30 mo.
