Fig. 8.

Inflammatory cell recruitment and cytokine/chemokine production are reduced in airways of mice repeatedly exposed to HDE following β₂-agonist treatments. Each day for 15 consecutive weekdays, mice (5 per group) were given nebulized salbutamol 30 min prior to intranasal HDE challenge. At 5 h following the final HDE exposure, mice were euthanized, BALF was collected, and lungs were removed for histological analysis. Inflammatory cells were recovered from BALF and quantified (A), and cytokines were measured in the BALF supernates (B). The entire experiment was performed twice, resulting in 10 mice per condition. *P < 0.05 vs. HDE alone (by 1-way ANOVA and Tukey's posttest).