Table 2.

Off-target effects of macrophage-targeting transgenic mice shown as percent of cells that express promoter-driven Cre

	LysM	c-fms	hCD68rtTA
Neutrophils	>90%	>90%	30–40%
Monocytes	90%	50–75%	60–70%
Eosinophils	5%	ND	<1%
Dendritic cells	50%	>90%*	70–80%
Resident AMø	>90%	>90%	1–8%

Previously published data describing LysM and c-fms promoter specificity (1, 22, 24, 32, 41, 43) is compared with hCD68-rtTA data, shown as percent of each cell type that activate the given promoter.

ND, not determined.

^*Data on DC from multiple organs, but not lung.