Fig. 10.

Summary of major findings. CH, presumably through ET-1, increases Ca²⁺ influx through ASIC1 in PASMC. Elevated intracellular Ca²⁺ levels leads to calcineurin-mediated dephosphorylation of NFATc3, allowing its nuclear import. PICK1 provides the scaffold for the interaction between ASIC1 and calcineurin, contributing to the NFATc3 activation process without affecting the ability of ASIC1 channels to conduct Ca²⁺. CaM, calmodulin; Cn, calcineurin.