Fig. 3.
ASIC1 contributes to ET-1-mediated vasoconstriction in isolated, pressurized small pulmonary arteries. Vasoconstriction (percent baseline diameter, A and B) and changes in arterial wall [Ca2+]i (ΔF340/F380, C and D) in response to endothelin-1 (ET-1, 10−10 to 10−8 M) in small pulmonary arteries from control (A and C) and CH-exposed (1 wk) (B and D) ASIC1+/+ and ASIC1−/− mice. Values are means ± SE, n = 5–7 animals/group. #P <0.05 vs. ASIC1+/+ mice analyzed by a two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.