Fig. 8.

PICK1 contributes to NFATc3 nuclear import downstream Ca²⁺ influx. Summary data showing EGFP nuclear (Fn)/cytosolic fluorescence (Fc) in mouse PASMC expressing NFATc3-EGFP treated with vehicle, ET-1 (100 nM, A), or ionomycin (0.1 μM, B) in the presence or absence of the PICK1 inhibitor FSC231 (50 μM). Values are means ± SE, n = 5 replicates/group from average of 20–25 cells/each replicate. *P < 0.05 vs. vehicle, #P < 0.05 vs. control mice, analyzed by a two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.