Table 2.

General linear model determination of magnitude of effects of diet, buffer insulin, buffer ketone, and all possible interactions among these factors on the left ventricular function following ischemia-reperfusion

	RPP		+dP/dt		−dP/dt
Factor	Magnitude	P Value	Magnitude	P Value	Magnitude	P Value
Base effect
Diet	(−) 7943	<0.001*	(−) 561	<0.001*	(−) 494	<0.001*
Buffer insulin	(+) 1031	0.53	(+) 55	0.67	(+) 100	0.37
Buffer ketone	(−) 1237	0.45	(−) 99	0.44	(−) 93	0.41
interactions
Diet-insulin	—	0.40	—	0.30	—	0.10
Diet-ketone	—	0.55	—	0.31	—	0.46
Insulin-ketone	—	0.19	—	0.05	—	0.06
Diet-insulin-ketone	—	0.45	—	0.14	—	0.45

Magnitude expressed as the difference in means of final functional parameter between aggregate groups stratified by diet, buffer insulin, and buffer ketone. For diet, (−) means that HFLCD has a lower value than CONT diet; for insulin, (+) means that the higher insulin level results in a greater value; for ketone, (—) means that the higher ketone level results in a lower value.

^*P < 0.05 for HFLCD compared with CONT diet with same perfusion buffer and perfusion condition.