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Diagram outlining scheduled events in the randomized crossover study: blood pressure (BP) and heart rate (HR) were measured at baseline, every 4 wk during study drug treatment, and after 4 wk of washout before crossover to the second drug. Microvascular blood flow, brachial artery blood flow, cardiac output, asymmetrical dimethylarginine (ADMA), and endothelial cell (EC) expression of p47phox were measured at baseline, after 12 wk of metoprolol, and after 12 wk of nebivolol.
