Table 3.
Hemodynamic and brachial conduit artery flow responses to handgrip exercise at 20 repetitions per min in hypertensive subjects treated with nebivolol vs. metoprolol
| Baseline (No Drug) | Metoprolol | Nebivolol | |
|---|---|---|---|
| Body weight, kg | 88.9 ± 3.6 | 90.3 ± 3.7† | 89.5 ± 3.5† |
| Resting MAP, mmHg | 105 ± 2 | 95 ± 3† | 97 ± 3† |
| RHG MAP, mmHg | 110 ± 2* | 101 ± 3*† | 103 ± 3*† |
| Resting HR, beat/min | 65 ± 1 | 56 ± 2† | 57 ± 2† |
| RHG HR, beat/min | 71 ± 1* | 60 ± 2*† | 62 ± 2*† |
| Resting FBF, ml/min | 141 ± 18 | 104 ± 19 | 112 ± 13 |
| RHG FBF, ml/min | 469 ± 50* | 398 ± 43* | 427 ± 37* |
| Resting cardiac output, l/min | 5.35 ± 0.4 | 4.83 ± 0.3 | 4.95 ± 0.4 |
| RHG cardiac output, l/min | 5.53 ± 0.4 | 4.82 ± 0.3 | 5.04 ± 0.4 |
| ADMA, μmol/l | 0.43 ± 0.03 | 0.50 ± 0.02 | 0.50 ± 0.03 |
| Ratio human/HUVEC p47Phox expression, arbitrary units | 0.43 ± 0.05 | 0.47 ± 0.12 | 0.44 ± 0.07 |
Values are means ± SE.
ADMA, asymmetrical dimethylarginine; FBF, forearm blood flow; RHG, rhythmic handgrip, EC endothelial cells; MAP, mean arterial pressure; HR, heart rate; HUVEC, human umbilical vein endothelial cell.
*
P < 0.05 vs rest;
†
P < 0.05 vs. baseline.