Table 1.

A summary of MMP-9 effects in the left ventricle following myocardial infarction

Model	Time of Post-MI Evaluation, days	Cellular Source	MMP-9 Expression	Post-MI Effects
MMP-9 null mice (25, 59, 76)	Up to 28	Global	↓	Deletion:
				↑Neutrophil apoptosis, macrophage phagocytic potential, and neovascularization
				↓Macrophage infiltration, collagen accumulation and LV enlargement and dysfunction
Transgenic overexpression of MMP-9 in macrophages (105)	5	Macrophage	↑	Overexpression in macrophages:
				↓Inflammation, macrophage polarization, ECM synthesis, and LV dysfunction
NF-κB p50 null mice (30)	56	Global deletion	↓	Deletion:
				↑Early survival
				↓LV dilation
Diabetic ischemia/reperfusion (5)	30-min ischemia/2-h reperfusion	Global	↑	Diabetes:
				↑Vascular remodeling and cardiovascular complications

MMP-9, matrix metalloproteinase-9; MI, myocardial infarction; LV, left ventricular; ECM, extracellular matrix.