Table 4.
Average characteristics of spontaneous AP-induced Ca2+ transients, systolic and diastolic [Ca2+]i measured by Indo-1 in the presence of DG (10 μmol/l)
| Time in DG, min | 0 | 1 | 3 | 5 | 10 | 15 | 20 |
|---|---|---|---|---|---|---|---|
| Systolic Ca2+, nM | 293.2 ± 19.4 | 331.9 ± 20.1 | 368.6 ± 23.2* | 398.6 ± 18.0* | 410.4 ± 31.0* | 412.6 ± 25.6* | 423.4 ± 21.0* |
| Diastolic Ca2+, nM | 124.3 ± 8.9 | 128.8 ± 10.9 | 139.2 ± 12.7* | 149.2 ± 11.5* | 157.7 ± 11.2* | 161.1 ± 12.9* | 161.8 ± 11.6* |
| Ca2+ transient, nM | 168.9 ± 22.6 | 203.1 ± 16.1 | 229.3 ± 15.2 | 249.4 ± 16.7* | 252.5 ± 30.1* | 251.5 ± 28.0* | 261.6 ± 23.0* |
| T-Pc, ms | 116.1 ± 9.4 | 98.3 ± 5.1 | 109.1 ± 3.8 | 107.2 ± 9.9 | 111.3 ± 5.3 | 110.5 ± 6.8 | 136 ± 18.6 |
| T-90c, ms | 287.2 ± 16.1 | 262.6 ± 25.7 | 295.4 ± 18.1 | 301.7 ± 19.6 | 320.5 ± 13.4 | 333.0 ± 16.5* | 365.2 ± 19.1* |
Values are means ± SE. A linear mixed-effects model with a Dunnett's post hoc adjustment to the P value was used to compare each time point in DG with the baseline (0 min). T-Pc, time to peak; T-90c, time to decay.
*
P < 0.05 vs. baseline (n = 5).