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Myocardial fatty acid oxidation and substrate utilization in cTKO and control mice. Oleate oxidation (A), glucose oxidation (B), and substrate reliance (percentage of oxygen consumption) (C) in cardiomyocyte-specific TXNIP knockout (cTKO) vs. control (lox/lox) hearts as assessed by isolated working mouse heart perfusions. Heart rate in lox/lox was 334 ± 33 and in cTKO 371 ± 5. Bars are expressed as means ± SE; n = 4 mice per group. *P < 0.05 (Student's t-test).
