Table 1.
HW/BW ratios, SBP, and HR of wild-type (2-copy), Npr1 gene-disrupted (1-copy), and Npr1 gene-duplicated (3-copy) control and drug-treated mice
| Groups/Indexes | HW/BW, mg/g | SBP, mmHg | HR, beats/min |
|---|---|---|---|
| 1-Copy vehicle | 6.5 ± 0.2‡ | 121.50 ± 4† | 446.5 ± 11† |
| 1-Copy + RA | 5.1 ± 0.2* | 111.40 ± 3* | 460.6 ± 10* |
| 1-Copy + SB | 5.2 ± 0.3* | 110.10 ± 3* | 457.6 ± 11* |
| 1-Copy + HB | 4.7 ± 0.2* | 108.60 ± 3* | 462.8 ± 10* |
| 2-Copy vehicle | 5.4 ± 0.2 | 100.9 ± 3 | 468.8 ± 10 |
| 2-Copy + RA | 4.9 ± 0.2 | 97.5 ± 2 | 462.3 ± 16 |
| 2-Copy + SB | 4.8 ± 0.1 | 98.1 ± 3 | 467.6 ± 14 |
| 2-Copy + HB | 4.5 ± 0.2* | 90.3 ± 3* | 479.1 ± 12* |
| 3-Copy vehicle | 4.7 ± 0.1‡ | 81.4 ± 2‡ | 487.5 ± 14‡ |
| 3-Copy + RA | 4.6 ± 0.2 | 87.1 ± 2 | 484.2 ± 10 |
| 3-Copy + SB | 4.4 ± 0.3 | 87.9 ± 2 | 483.9 ± 16 |
| 3-Copy + HB | 4.4 ± 0.2* | 86.3 ± 3* | 485.2 ± 12* |
Values are expressed as means ± SE (n = 8). Heart weight-to-body weight (HW/BW) ratio, systolic blood pressure (SBP), and heart rate (HR) of control, retinoic acid (RA), sodium butyrate (SB) and hybrid (HB) drug-treated mice. Statistical significance expressed as
†
P < 0.05,
‡
P < 0.01 compared with 2-copy control;
*
P < 0.05,
§
P < 0.01 compared with vehicle-treated controls within the group.