Table 1.

Morphometric characteristics and 24-hour urine and baseline hemodynamics

	0.6% Pi	1.2% Pi
Number of animals	13	13
Body weight, g	492 ± 9	496 ± 11
Heart weight/body weight, mg/g	2.67 ± 0.04	2.89 ± 0.10
Heart weight/tibial length, mg/mm	30.9 ± 0.7	33.7 ± 1.5
Lung weight/body weight, mg/g	4.86 ± 0.19	4.87 ± 0.23
Food intake, g/day	19.8 ± 0.7	19.0 ± 1.7
Serum Levels
Creatinine, mg/dl	0.37 ± 0.01	0.35 ± 0.01
Calcium, mg/dl	9.31 ± 0.10	9.46 ± 0.08
Sodium, mmol/l	132 ± 0.46	132 ± 0.27
Potassium, mmol/l	3.98 ± 0.06	4.03 ± 0.06
Phosphate, mg/dl	3.70 ± 0.10	3.76 ± 0.08
24-hour urinary excretion
Urine volume, ml/day	16.5 ± 1.4	13.6 ± 1.3
Creatinine, mg/day	14.9 ± 0.8	13.0 ± 1.2
Calcium, mg/day	1.1 ± 0.1	0.8 ± 0.1
Sodium, mmol/day	3.1 ± 0.2	2.3 ± 0.2
Potassium, mmol/day	4.6 ± 0.2	5.1 ± 0.2
Phosphate, mg/day	12 ± 1	77 ± 5*
Creatinine clearance, ml/min	2.83 ± 0.17	2.64 ± 0.30
Hemodynamic variables
Tail cuff systolic BP under anesthesia, mmHg	95 ± 2	109 ± 3*
Mean BP, mmHg	93 ± 4	120 ± 5*
HR, beats/min	333 ± 9	355 ± 5†
Baseline RSNA to noise ratio	5.5 ± 1.1	4.0 ± 0.6
Tail cuff systolic BP after decerebration
Mean BP, mmHg	96 ± 6	100 ± 7
HR, beats/min	410 ± 21	400 ± 12
Baseline RSNA to noise ratio	5.2 ± 1.4	6.4 ± 1.3

Values are expressed as means ± SE BP, blood pressure; HR, heart rate; RSNA, renal sympathetic nerve activity.

^*P < 0.01,

^†P < 0.05 compared with 0.6% Pi.