Fig. 6.
Contractile properties in isolated EDL and soleus muscles from skeletal myofiber-specific gene-ablated mice. Force was measured as a function of stimulation frequency to assess the contractile function of each muscle. A: soleus 21 days following tamoxifen (n = 4–6 muscles per group). B: EDL 21 days following tamoxifen (n = 5 or 6 muscles per group). C: soleus 56 days following tamoxifen (n = 5–7 muscles per group). D: EDL 56 days following tamoxifen (n = 6–7 muscles per group). The EDL muscle, 56 days after tamoxifen delivery, showed a significant right shift in the force-frequency curve. There were no significant differences in any other muscle between skmVEGF−/− and VEGF+/+. Values are expressed as means ± SE. *Significant difference (P < 0.05) between skmVEGF−/− and VEGF +/+ muscles.