Table 3.
Morphometric measurements following right pneumonectomy
Left Cranial Lobe |
Left Middle Lobe |
Left Caudal Lobe |
||||
---|---|---|---|---|---|---|
Sham | PAB | Sham | PAB | Sham | PAB | |
Lung volume, ml/kg | ||||||
Immersion | 17.82 ± 4.01 | 19.21 ± 4.87 | 11.02 ± 1.33 | 9.39 ± 0.19* | 32.46 ± 2.93 | 31.11 ± 3.44 |
Cavalieri | 15.36 ± 4.35 | 14.64 ± 3.81 | 9.42 ± 2.09 | 6.49 ± 0.56* | 27.85 ± 3.84 | 25.25 ± 3.71 |
Morphometric hematocrit | ||||||
Morphometric hematocrit | 0.541 ± 0.006 | 0.539 ± 0.045 | 0.555 ± 0.010 | 0.519 ± 0.061 | 0.521 ± 0.024 | 0.538 ± 0.042 |
Harmonic mean thickness of diffusion barrier (τhb) | ||||||
τhb, μm | 0.861 ± 0.034 | 0.821 ± 0.076 | 0.892 ± 0.019 | 0.826 ± 0.084 | 0.817 ± 0.013 | 0.788 ± 0.053 |
Volume density per unit lung volume | ||||||
Coarse parenchyma§ | 0.9477 ± 0.0028 | 0.9112 ± 0.0105* | 0.9553 ± 0.0137 | 0.9294 ± 0.0104* | 0.9447 ± 0.0207 | 0.9075 ± 0.0156* |
Fine parenchyma@ | 0.9371 ± 0.0013 | 0.8892 ± 0.0094* | 0.9446 ± 0.0117 | 0.9032 ± 0.0071* | 0.9335 ± 0.0194 | 0.8919 ± 0.0132* |
Septum† | 0.0951 ± 0.0179 | 0.0783 ± 0.0082 | 0.0963 ± 0.0336 | 0.0815 ± 0.0048 | 0.1118 ± 0.0168 | 0.0789 ± 0.0076* |
Volume density per unit septum volume | ||||||
Capillary blood | 0.5797 ± 0.0118 | 0.5829 ± 0.0236 | 0.5762 ± 0.0169 | 0.5915 ± 0.0101 | 0.5845 ± 0.0178 | 0.6229 ± 0.0374 |
Septal extravascular tissue | 0.4203 ± 0.0118 | 0.4171 ± 0.0236 | 0.4238 ± 0.0169 | 0.4085 ± 0.0101 | 0.4155 ± 0.0178 | 0.3771 ± 0.0374 |
Epithelium | 0.1543 ± 0.0030 | 0.1674 ± 0.0169 | 0.1503 ± 0.0061 | 0.1534 ± 0.0187 | 0.1519 ± 0.0057 | 0.1498 ± 0.0225 |
Type I | 0.0967 ± 0.0037 | 0.1100 ± 0.0063* | 0.0978 ± 0.0029 | 0.1013 ± 0.0163 | 0.0925 ± 0.0060 | 0.0974 ± 0.0189 |
Type II | 0.0577 ± 0.0054 | 0.0574 ± 0.0108 | 0.0524 ± 0.0048 | 0.0520 ± 0.0073 | 0.0594 ± 0.0087 | 0.0523 ± 0.0100 |
Interstitium§ | 0.1636 ± 0.0037 | 0.1462 ± 0.0071* | 0.1720 ± 0.0144 | 0.1503 ± 0.0195 | 0.1612 ± 0.0156 | 0.1292 ± 0.0180* |
Collagen@ | 0.1247 ± 0.0050 | 0.1110 ± 0.0086* | 0.1357 ± 0.0131 | 0.1066 ± 0.0119* | 0.1250 ± 0.0137 | 0.0960 ± 0.0140* |
Cells and matrix | 0.0389 ± 0.0033 | 0.0352 ± 0.0061 | 0.0363 ± 0.0043 | 0.0437 ± 0.0101 | 0.0362 ± 0.0022 | 0.0332 ± 0.0077 |
Endothelium | 0.1003 ± 0.0086 | 0.1024 ± 0.0096 | 0.1011 ± 0.0061 | 0.1016 ± 0.0054 | 0.1005 ± 0.0030 | 0.1024 ± 0.0026 |
Surface density per unit septum volume | ||||||
Alveolar surface, cm−1 | 3,955 ± 301 | 3,853 ± 476 | 3,878 ± 232 | 3,740 ± 676 | 3,813 ± 195 | 3,990 ± 354 |
Capillary surface,† cm−1 | 4,001 ± 136 | 4,451 ± 547 | 3,828 ± 258 | 4,576 ± 438* | 4,035 ± 157 | 4,493 ± 232* |
Values are means ± SD.
P ≤ 0.05, PAB vs. Sham banding in the same lobe by two-tailed unpaired t-test. †P ≤ 0.05, §P ≤ 0.01, @P ≤ 0.001, PAB vs. Sham banding across all lobes by repeated-measures ANOVA.