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. 2016 Jul 30;7:99. doi: 10.1186/s13287-016-0358-4

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — WGBS revealed CpG methylation alterations in iPMSCs compared with fibroblast cells. a Volcano plot depicting the DMRs in iPMSCs compared with fibroblasts (Fib), with the horizontal axis representing methylation differences and the vertical axis representing the standard deviation (sd) in t statistics. b Box plot showing the distribution of CpG sites based on different methylation levels. c Bar plot showing the enrichment of DMRs in different genomic features. d Distribution of DMR distances to its closest TSS; controls are generated by randomly sampling 60,000 regions of 200 bp from hg19