Table 3.
GM volume regions positively correlated with the scores on the FCSRT for the whole group of patients (group ABC) using VBM
Group (score) | P | Brain region | Side | BA | k | x | y | z | T |
---|---|---|---|---|---|---|---|---|---|
ABC (TR), n = 138 | P FWE = 0.05 | Parahippocampal g. | L | 35 | 212 | –26 | –15 | –27 | 5.59 |
Hippocampus | NA | 33 | –21 | –27 | –12 | 5.13 | |||
Parahippocampal g. | R | 35 | 154 | 26 | –10 | –32 | 5.48 | ||
P = 0.001 | Hippocampus | L | NA | 1227/4337 | –28 | –10 | –24 | 5.02 | |
Parahippocampal g. | 28, 34–36 | 818/4337 | –26 | –15 | –27 | 5.59 | |||
Temporal pole | 38 | 281/4337 | –31 | 6 | –21 | 4.25 | |||
Temporal lobe | 38 | 905/4337 | –31 | 6 | –21 | 4.25 | |||
Amygdala | NA | 372/4337 | –28 | –3 | –21 | 4.23 | |||
Parahippocampal g. | R | 20, 28, 36 | 812/1700 | 27 | –15 | –33 | 4.56 | ||
Hippocampus | NA | 172/1700 | –25 | –9 | –24 | 3.91 | |||
Temporal pole | NA | 20/53 | 37 | 13 | –18 | 3.39 | |||
Hippocampus | NA | 99/1200 | –25 | –9 | –24 | 3.91 | |||
ABC (FR), n = 138 | P = 0.001 | Hippocampus | L | NA | 470/1188 | –24 | –34 | –3 | 3.82 |
Parahippocampal g. | 28, 35 | 295/1188 | –19 | –28 | –13 | 3.97 | |||
Amygdala | NA | 25/1188 | –21 | –9 | –12 | 3.26 | |||
Hippocampus | R | NA | 264/572 | 25 | –35 | 1 | 3.65 | ||
Parahipocampal g. | 27 | 104/572 | 21 | –34 | –3 | 3.76 | |||
ABC (DTR), n = 138 | P FWE = 0.05 | Parahippocampal g. | L | 35 | 25 | –26 | –15 | –27 | 5.06 |
P = 0.001 | Parahippocampal g. | L | 28, 34–36 | 1646/2401 | –26 | –15 | –27 | 5.06 | |
Hippocampus | NA | 711/2401 | –27 | –10 | –24 | 4.38 | |||
Temporal lobe | 20 | 151/2401 | –37 | –12 | –25 | 3.29 | |||
Amygdala | NA | 313/2401 | –25 | 0 | –18 | 3.65 | |||
Parahippocampal g. | R | 28, 35, 36 | 496/850 | 25 | –12 | –36 | 4.04 | ||
Hippocampus | NA | 36/850 | 27 | –10 | –25 | 3.61 | |||
Temporal lobe | 20 | 68/850 | 37 | 13 | –18 | 3.39 |
Statistical analyses were performed including age, gender, education level, total GM volume and centre as nuisance covariates, with a threshold of P = 0.05, FWE or P = 0.001, uncorrected, including a minimal k of 50 voxels
GM grey matter, FCSRT Free and Cued Selective Reminding Test, VBM voxel-based morphometry, L left, R right, BA Brodmann area, k cluster size in voxel (specific region’s volume/cluster’s global volume), x, y, z Talairach coordinates, T T value, g. gyrus, DTR delayed total recall, FR free recall, FWE family-wise error, TR total recall