Table 6.

Comparisons of allelic frequencies of MEFV mutations of FMF patients with or without accompanying rheumatic diseases

		FMF
		Rheumatic diseases (+)	Rheumatic diseases (–)
		2n = 52	2n = 332	p	pc
Exon10	M694I	4 (7.7 %) [1/26 (3.8 %)]	48 (14.5 %) [4/166 (2.4 %)]	0.185	2.7738
	P751L	0	1 (0.3 %)	0.865	12.9687
	G632S	0	1 (0.3 %)	0.865	12.9687
Exon3	R410H	0	1 (0.3 %)	0.865	12.9687
	R408Q	8 (15.4 %) [2/26 (7.7 %)]	23 (6.9 %) [0/166 (0 %)]	0.043	0.6419
	P369S	8 (15.4 %) [2/26 (7.7 %)]	25 (7.5 %) [0/166 (0 %)]	0.060	0.9050
	R354Q	0	1 (0.3 %)	0.865	12.9687
Exon2	G304R	3 (5.8 %) [0/26 (0 %)]	8 (2.4 %) [1/166 (0.6 %)]	0.176	2.6382
	E225K	0	1 (0.3 %)	0.865	12.9687
	R202Q	3 (5.8 %)	14 (4.2 %)	0.411	6.1680
	E148Q	23 (44.2 %) [4/26 (15.4 %)]	127 (38.3 %) [19/166 (11.4 %)]	0.411	6.1702
	P115R	0	0
	L110P	8 (15.4 %) [0/26 (0 %)]	37 (11.1 %) [1/166 (0.6 %)]	0.377	5.6513
Exon1	E84K	1 (1.9 %)	11 (3.3 %)	0.500	7.4946
	R80H	0	0

Values are shown as n (%) [% of homozygote]. FMF familial Mediterranean fever, pc corrected p value