Table 2.
Circulating biomarkers grouped according to DanaPoint classification
| Control | All PH | PAH | LD | CTEPH | |
|---|---|---|---|---|---|
| TSP-1 [ng/mL] | 82.1 ± 15.8 | 1114* ±136 | 1025* ±161 | 799* ± 237 | 1852*,**,*** ±428 |
| bigET [pg/mL] | 1.22 ± 0.34 | 2.96* ±0.34 | 3.05* ±0.48 | 2.29 ± 0.53 | 4.06* ±0.75 |
| PDGF-ββ [pg/mL] | 152 ± 11 | 784* ±161 | 905 ± 253 | 652* ±145 | 382 ± 173 |
| PF4 [pg/mL] | 2.12 ± 0.25 | 3.05(*) ±0.29 | 2.81 ± 0.30 | 3.60 ± 0.72 | 2.95 ± 0.86 |
| SDF-1α [pg/mL] | 71.6 ± 8.7 | 124.5* ±14.2 | 128 ± 21.4 | 121 ± 17.1 | 116 ± 46.1 |
| NT-proBNP [pg/mL] | 128.0 ± 49 | 1212* ±214 | 1070* ±213 | 1529 ± 662 | 1296* ±495 |
| Creatinine [mg/dL] | 0.77 ± 0.22 | 1.01 ± 0.32* | 1.06 ± 0.32* | 0.95 ± 0.26 | 0.94 ± 0.35 |
| Uric acid [mg/dL] | 5.09 ± 1.41 | 7.56 ± 2.46* | 7.20 ± 2.13* | 7.70 ± 2.12* | 8.93 ± 4.01* |
| Hb [g/dL] | 14.2 ± 1.3 | 14.2 ± 2.4 | 14.6 ± 2.5 | 13.9 ± 2.3 | 13.5 ± 1.9 |
| LDH [U/L] | 199.9 ± 66.0 | 285.6 ± 91.0* | 277.6 ± 62.0* | 279.5 ± 70.9* | 324.2 ± 173.2* |
| Bilirubin [mg/dL] | 0.55 ± 0.20 | 0.80 ± 0.50 | 0.78 ± 0.47 | 0.78 ± 0.39 | 0.88 ± 0.75 |
TSP-1 thrombospondin 1, bigET big Endothelin, PDGF-ββ platelet derived growth factor ββ, PF4 platelet factor 4, SDF-1α stroma derived factor 1α, NT-proBNP N-terminal pro-brain natriuretic peptide
Data is expressed as mean ± SD, *p < 0.05 vs. Control, **p < 0.05 vs. PAH, ***p < 0.05 vs. LD, marks in brackets signify statistical trends (0.05 < p < 0.01)