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. 2016 Jul 29;9:33. doi: 10.1186/s13072-016-0079-z

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Time-course analysis. a Demethylation of 10 DMRs. Average CpG methylated fractions in Hm06 donor monocytes (0 h) and cells collected at different time points during differentiation into macrophages. Related to Additional file 9: Figure S5. b Time course of chromatin accessibility (GpC methylation in NOMe experiments) and DNA CpG methylation in DMR33. Average CpG and GpC methylated fractions in Hm10 donor monocytes (0 h) and cells collected at different time points during differentiation into macrophages. The transition from lower to higher GpC methylated fraction is indicative of an increase in chromatin accessibility. GCG motifs were excluded due to ambiguity between CpG- endogenous- and GpC-enzymatic-methylation. Related to Additional file 10: Figure S6. c 5-hydroxymethyl-cytosine (5hmC) level increases during differentiation. Average 5hmC and 5mC (5-methylcytosine) fractions in monocytes (0 h) and cells collected at different time points (DMR33 from donor Hm10). Related to Additional file 14: Figure S7