Table 2. Multivariable Models for Overall Survival and Progression-Free Survival of BRCA wild type OvCa patients with different BRCAness status.
Overall Survival | Progression-Free Survival | |||||||
---|---|---|---|---|---|---|---|---|
3-Year Rate, % (95% CI) | 5-Year Rate, % (95% CI) | HR (95% CI) | P Value | 3-Year Rate, % (95% CI) | 5-Year Rate, % (95% CI) | HR (95% CI) | P Value | |
BRCAness | ||||||||
Hypomutation | 40(26-60) | 15 (7-36) | 1 [Reference] | 8(2-27) | 0* | 1 [Reference] | ||
Intermediate | 61(53-71) | 34(16-35) | 0.60(0.39-0.91) | 0.016 | 16(10-26) | 12(6-21) | 0.80(0.53-1.21) | 0.29 |
BRCAness | 75(56-100) | 55(32-93) | 0.33(0.15-0.69) | 0.004 | 31(13-75) | 21(6-68) | 0.51(0.24-1.08) | 0.077 |
Tumor Stage | ||||||||
II | 89(71-100) | 67(36-100) | 1 [Reference] | 75(50-100) | 37(9-100) | 1 [Reference] | ||
III | 59(51-68) | 21(14-31) | 2.34(0.73-7.43) | 0.15 | 13(8-21) | 8(4-16) | 4.06(1.27-12.92) | 0.018 |
IV | 48(33-70) | 34(20-58) | 2.40(0.71-8.08) | 0.16 | 14(5-39) | 14 (5-39) | 4.22(1.25-14.22) | 0.020 |
Age increase of 1.0 ye | 1.02(1.00-1.03) | 0.04 | 0.99(0.98-1.01) | 0.34 |
all patients in the hypomutation group lived no more than 5-years