Table 2.
Cox Proportional Hazards Regression Model Showing the Association of Variables With Overall Survival
| Variable | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| Factors Selected | ||||
| Tumor size, cm | ||||
| <12 | 1 [Reference] | NA | 1 [Reference] | NA |
| ≥12 | 1.47 (0.84–2.58) | .17 | 1.78 (1.00–3.17) | .05 |
| Nodal status | ||||
| Negative | 1 [Reference] | NA | 1 [Reference] | NA |
| Positive | 5.54 (2.01–15.27) | .001 | 5.89 (2.05–16.87) | .001 |
| Not harvested | 1.55 (0.74–3.25) | .25 | 1.44 (0.65–3.22) | .37 |
| Resection margin | ||||
| R0 | 1 [Reference] | NA | 1 [Reference] | NA |
| R1 | 2.94 (1.62–5.33) | <.001 | 2.83 (1.51–5.30) | .001 |
| Factors Not Selected | ||||
| Age, y | ||||
| <65 | 1 [Reference] | NA | NA | NA |
| ≥65 | 1.10 (0.55–2.18) | .79 | NA | NA |
| Sex | ||||
| Male | 1.09 (0.67–1.78) | .73 | NA | NA |
| Female | 1 [Reference] | NA | NA | NA |
| Functional tumor | ||||
| No | 1 [Reference] | NA | NA | NA |
| Yes | 1.48 (0.84–2.59) | .17 | NA | NA |
| Cortisol-secreting tumor | ||||
| No | 1 [Reference] | NA | NA | NA |
| Yes | 1.75 (0.89–3.46) | .11 | NA | NA |
| T stage | ||||
| I/II | 1 [Reference] | NA | NA | NA |
| III/IV | 1.96 (1.08–3.54) | .03 | NA | NA |
| Capsular invasion | ||||
| No | 1 [Reference] | NA | NA | NA |
| Yes | 2.45 (1.18–5.11) | .02 | NA | NA |
Abbreviations: HR, hazard ratio; NA, not applicable.