Table 1.
Newly identified genetic susceptibility loci for colorectal cancer.
| Effect allele frequency* | Discovery | Asian 1 | Asian 2 | Combined | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP Chr:Pos (b37) | Alleles Eff/Alt | European | Asian | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | OR (95% CI) |
P value | I2 |
| rs35360328:40924962 | A/T | 0.16 | 0.09 | 1.14 (1.09–1.19) |
2.4E-08 | † | † | 1.19 (1.01–1.41) |
0.04 | 1.14 (1.09–1.19) |
3.1E-09 | 0 |
| rs8124813:66442435 | G/C | 0.58 | 0.79 | 1.09 (1.05–1.12) |
2.5E-08 | 1.03 (0.94–1.14) |
0.47 | 1.05 (0.97–1.15) |
0.21 | 1.09 (1.05–1.11) |
2.0E-08 | 0 |
| rs1119016410:101351704 | G/A | 0.29 | 0.21 | 1.10 (1.05–1.14) |
8.4E-07 | 1.04 (0.94–1.14) |
0.46 | 1.14 (1.03–1.25) |
7.8E-03 | 1.09 (1.06–1.12) |
4.0E-08 | 0 |
| rs318450412:111884608 | C/T | 0.53 | 0.995 | 1.09 (1.06–1.12) |
1.7E-08 | † | † | † | † | 1.09 (1.06–1.12) |
1.7E-08 | 0 |
| rs7320812012:117747590 | G/T | 0.11 | <0.001 | 1.16 (1.11–1.23) |
2.8E-08 | † | † | † | † | 1.16 (1.11–1.23) |
2.8E-08 | 0 |
| rs606682520:47340117 | A/G | 0.64 | 0.70 | 1.07 (1.03–1.10) |
8.7E-05 | 1.12 (1.03–1.21) |
5.6E-03 | 1.18 (1.09–1.27) |
2.2E-05 | 1.09 (1.06–1.12) |
4.4E-09 | 0.69‡ |
| rs49462606:117822993 | T/C | 0.53 | 0.44 | 1.08 (1.05–1.11) |
4.5E-07 | 1.06 (0.98–1.14) |
0.14 | 1.05 (0.98–1.13) |
0.15 | 1.07 (1.05–1.10) |
6.3E-08 | 0 |
Chr, chromosome; CI, confidence interval; OR, odds ratio; Pos, position; SNP, single-nucleotide polymorphism.
*
Effect allele frequency (MAF) from 1000 Genomes Project June 2011 release. European frequency is based on CEU+FIN+GBR+IBS+TSI. Asian frequency is based on CHB+CHS+JPT.
†
SNP not available.
‡
P value for Cochran’s Q test of heterogeneity=0.038.