Table 1.
itga8 mutant fish show partially penetrant craniofacial defects
| Genotypea | nb | Me-PQ fusionc | Sy-Ch fusionc | Sy shortc |
|---|---|---|---|---|
| Siblings | 611 | 0% | 0% | 0% |
| itga8b1161 (zyg) | 129 | 26% | 64% | 42% |
| itga8b1161 (mat+zyg) | 54 | 26% | 55% | 43% |
| itga8oz6 | 41 | 9% | 34% | 73% |
| itga8oz7 | 18 | 28% | 44% | 67% |
| itga8oz6/oz7 | 16 | 38% | 31% | 78% |
| itga8oz6/b1161 | 30 | 5% | 38% | 53% |
| fras1te262 | 147 | 19% | 57% | 68% |
a
See Methods for details. “Siblings” includes both wild type and individuals heterozygous for b1161. itga8b1161 (zyg) fish are derived from incross of b1161 heterozygotes; itga8b1161 (mat+zyg) fish from an incross of b1161 homozygotes.
b
n, number of individuals for which both left and right sides of the face were scored for cartilage defects.
c
Fish were labeled with alcian/alizarin-stain to reveal cartilage and bone defects at 6 dpf. Individual defects are shown as the percentage of occurrence per side. Me-PQ fusion = fusion between Meckel's and palatoquadrate cartilages; Sy-Ch fusion = fusion between symplectic and ceratohyal cartilages; Sy short = shortened symplectic cartilage.