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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Dev Biol. 2016 Jun 2;416(1):136–148. doi: 10.1016/j.ydbio.2016.05.035

Table 2.

Penetrance of cartilage defects in fras1/itga8 single and double mutants.

Genotypea nb Me-Pq fusionc Sy-Ch fusionc Sy shortc
Siblings 225 2% 0% 0%
itga8b1161 78 36% 18% 51%
fras1b1048 63 60% 50% 72%
fras1b1048; itga8b1161 33 77% 55% 88%
a

See methods for details. The “Siblings” category includes genetically wild type fish, siblings heterozygous for fras1, siblings heterozygous for itga8, and siblings trans-heterozygous for both genes; the heterozygous siblings appear phenotypically normal.

b

n, number of individuals for which both left and right sides of the face were scored for cartilage defects.

c

Fish scored live for skeletal defects at 7 dpf, using sox9a:EGFP expression to mark cartilages. Individual defects are shown as the percentage of occurrence per side. Me-PQ fusion = fusion between Meckel's and palatoquadrate cartilages; Sy-Ch fusion = fusion between symplectic and ceratohyal cartilages; Sy short = shortened symplectic cartilage.