Table 1.
Day | 0 | 19 | 19 | 20 | 23 | 26 | 27 | Termination |
---|---|---|---|---|---|---|---|---|
Procedure | Implant | OE-MRI* | Pimonidazole | IR 15 Gy | CCI-103F | OE-MRI | IR 15 Gy | VQT, 10%BW loss 90 days |
Group 1 No IR |
n=4 | ✓ | ||||||
Group 2 2×15 Gy Air |
n=9 | Air → O2 R1, IBT, R1 |
Air | Air → O2 R1, IBT, R1 |
Air | ✓ | ||
Group 3 2×15 Gy O2 |
n=9 | Air → O2 R1, IBT, R1 |
O2 | Air → O2 R1, IBT, R1 |
O2 | ✓ | ||
Group 4 IHC |
n=3 | Air → O2 R1, IBT, R1 |
O2 | O2 (n=2) | OE-MRI, O2, sacrifice |
R1, IBT, R1 indicates baseline R1 map followed by interleaved R2* maps and T1-weighted images during transition to oxygen followed by final R1 map with O2 breathing.