Table 1.

Chronological Scheme of Measurements and Irradiation

Day	0	19	19	20	23	26	27	Termination
Procedure	Implant	OE-MRI*	Pimonidazole	IR 15 Gy	CCI-103F	OE-MRI	IR 15 Gy	VQT, 10%BW loss 90 days
Group 1 No IR	n=4							✓
Group 2 2×15 Gy Air	n=9	Air → O2 R1, IBT, R1		Air		Air → O2 R1, IBT, R1	Air	✓
Group 3 2×15 Gy O2	n=9	Air → O2 R1, IBT, R1		O2		Air → O2 R1, IBT, R1	O2	✓
Group 4 IHC	n=3	Air → O2 R1, IBT, R1	O2	O2 (n=2)	OE-MRI, O2, sacrifice

^*R₁, IBT, R₁ indicates baseline R₁ map followed by interleaved R₂* maps and T₁-weighted images during transition to oxygen followed by final R₁ map with O₂ breathing.