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. Author manuscript; available in PMC: 2017 Sep 28.
Published in final edited form as: Cancer Lett. 2016 Jun 3;380(1):69–77. doi: 10.1016/j.canlet.2016.06.003

Table 2.

Dunning R3327-AT1 Prostate Tumor Characteristics and Results for Hypofractionation

AT1 Tumor Tumor Size (cm3) BOLD (%ΔSI) TOLD (%ΔSI) ΔR1 (s−1) ΔR2* (s−1)
pre1F pre2F pre1F pre2F pre1F pre2F pre1F pre2F pre1F pre2F VQT (days) VDT (days)
graphic file with name nihms798600t1.jpg 1 1.0 2.7 −2.10±0.54 2.36±0.76 −0.40±0.21 2.25±0.58 0.0539±0.0010 ND 5.1±1.7 1.3±1.0 19 25
2 0.9 1.6 3.62±0.29 2.59±0.33 2.13±0.25 1.65±0.20 0.0475±0.0017 ND 0.3±1.8 −1.7±1.0 18 28
3 0.9 1.2 −0.60±0.47 5.18±0.53 −0.19±0.15 1.34±0.79 0.0928±0.0017 0.0567±0.0011 −3.5±2.4 2.6±1.7 21 26
4 1.2 2.3 4.09±1.59 −0.33±0.33 2.51±0.24 −0.46±0.09 0.0374±0.0013 0.0313±0.0008 −0.8±2.3 0.9±1.6 17 33
5 1.2 2.5 2.43±0.56 1.86±0.34 0.79±0.04 1.00±0.17 0.0149±0.0013 0.0142±0.0011 9.1±1.6 −0.1±1.0 7 28
6 1.4 2.2 4.01±0.33 3.01±0.46 1.05±0.34 1.53±0.15 0.0099±0.0023 0.0139±0.0015 −0.3±2.1 −0.1±2.7 23 39
7 2.1 3.1 −0.44±0.26 0.73±0.17 0.59±0.11 0.98±0.17 −0.006±0.0008 0.0326±0.0008 −0.4±0.8 −0.3±0.5 31 49
8 0.9 1.0 3.76±0.63 3.86±0.87 2.11±0.30 2.24±0.32 0.0365±0.0006 0.0252±0.0151 0.6±2.1 0.6±1.6 13 26
9 1.2 2.0 3.29±0.46 2.28±0.27 0.72±0.57 1.59±0.40 0.0472±0.0023 0.0070±0.0031 −0.6±0.9 0.3±1.2 10 25
Inhaled Air Mean±SEM 1.2±0.1 2.0±0.2 2.0±0.8 2.4±0.5 1.0±0.3 1.35±0.27 0.0371±0.0100 0.026±0.006 1.1±1.3 0.4±0.4 18±2 32±3
graphic file with name nihms798600t2.jpg 10 1.5 1.7 −0.93±0.55 2.52±0.59 0.32±0.16 1.62±0.29 0.0460±0.0018 ND −1.0±1.7 −3.2±1.1 28 39
11 1.1 1.7 −3.26±0.62 3.29±0.62 1.07±0.14 1.63±0.19 0.1213±0.0023 0.0070±0.0018 2.1±1.6 −0.3±1.1 24 30
12 0.7 1.1 1.43±0.20 0.61±0.40 0.76±0.12 1.19±0.17 0.0393±0.0018 0.0460±0.0013 1.7±2.4 1.0±1.8 23 32
13 0.9 0.9 4.52±0.95 4.77±0.64 1.97±0.19 1.72±0.24 0.0677±0.0014 0.0015±0.0022 −1.0±1.3 0.3±2.3 31 43
14 1.2 2.5 3.55±1.29 3.24±0.45 0.77±0.26 2.53±0.22 0.0520±0.0021 0.0601±0.0036 −1.5±1.8 −0.3±1.0 25 40
15 1.1 0.9 7.94±0.80 2.22±0.47 1.40±0.33 1.68±0.20 0.0308±0.0017 0.0730±0.0013 −3.3±1.3 −2.4±1.6 28 36
16 1.6 2.7 1.64±0.27 2.50±0.44 1.25±0.15 1.57±0.15 0.0310±0.0011 0.0136±0.0013 −0.8±1.2 −2.3±0.8 30 42
17 1.7 2.6 2.60±0.60 3.43±0.57 1.03±0.23 3.00±0.56 0.0011±0.0016 0.0085±0.0008 5.4±1.4 −3.3±0.9 28 48
18 1.7 3.1 4.77±0.64 3.47±0.51 1.51±0.14 2.13±0.20 0.0069±0.0010 0.0161±0.0009 −1.2±1.1 −0.5±1.1 37 42
Inhaled Oxygen Mean±SEM 1.3±0.1 1.9±0.3 2.5±1.1 2.9±0.4 1.1±0.2 1.9±0.2 0.044±0.012 0.028±0.010 0.04±0.86 −1.2±0.5 28±1 39±2
Overall Mean±SEM 1.3±0.1 2.1±0.2 2.2±0.7 2.6±0.3 1.1±0.2 1.6±0.2 0.041±0.007 0.027±0.006 0.55±0.75 −0.42±0.38 20±2 32±2
P-valuea 0.7093a 0.7160a 0.7351a 0.4576a 0.8241a 0.1144a 0.6570a 0.8449a 0.5155a 0.0271a 0.0006a 0.0356a
P-valueb,c 0.4235b, 0.5799 c 0.9822b 0.4242b 0.7071b 0.7353b <0.0001 c <0.0001 c

Data values reported as mean ± standard error of the mean (SEM) from voxels averaged over two slices for BOLD, TOLD, and R2* and three slices for R1.

ND- missing values due to logistic issues.

a

– P-values for comparisons (two-sample t-tests) of each covariate for differences in inhaling air vs. oxygen.

b

– P-values for comparisons (two-sample t-tests) of each covariate for differences in pre1F- vs. pre2F controlled treatment groups (inhaling air vs. oxygen)

c

– P-values for comparisons (general linear analysis) in differences of initial, VDT, or VQT tumor volumes vs. control tumor volumes (not shown in table).

VDT: time the tumors reached 2 times the initial irradiated tumor volume; VQT: time the tumors reached 4 times the initial irradiated tumor volume

BOLD: blood-oxygenation level dependent; TOLD: tissue-oxygenation level dependent; ΔR1: intrinsic longitudinal relaxation rate; ΔR2*: apparent transverse relaxation rate

pre1F- measurements before the first irradiation

pre2F- measurements six days after the first irradiation and before the second irradiation