Table 2.
AT1 Tumor | Tumor Size (cm3) | BOLD (%ΔSI) | TOLD (%ΔSI) | ΔR1 (s−1) | ΔR2* (s−1) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
pre1F | pre2F | pre1F | pre2F | pre1F | pre2F | pre1F | pre2F | pre1F | pre2F | VQT (days) | VDT (days) | ||
1 | 1.0 | 2.7 | −2.10±0.54 | 2.36±0.76 | −0.40±0.21 | 2.25±0.58 | 0.0539±0.0010 | ND | 5.1±1.7 | 1.3±1.0 | 19 | 25 | |
2 | 0.9 | 1.6 | 3.62±0.29 | 2.59±0.33 | 2.13±0.25 | 1.65±0.20 | 0.0475±0.0017 | ND | 0.3±1.8 | −1.7±1.0 | 18 | 28 | |
3 | 0.9 | 1.2 | −0.60±0.47 | 5.18±0.53 | −0.19±0.15 | 1.34±0.79 | 0.0928±0.0017 | 0.0567±0.0011 | −3.5±2.4 | 2.6±1.7 | 21 | 26 | |
4 | 1.2 | 2.3 | 4.09±1.59 | −0.33±0.33 | 2.51±0.24 | −0.46±0.09 | 0.0374±0.0013 | 0.0313±0.0008 | −0.8±2.3 | 0.9±1.6 | 17 | 33 | |
5 | 1.2 | 2.5 | 2.43±0.56 | 1.86±0.34 | 0.79±0.04 | 1.00±0.17 | 0.0149±0.0013 | 0.0142±0.0011 | 9.1±1.6 | −0.1±1.0 | 7 | 28 | |
6 | 1.4 | 2.2 | 4.01±0.33 | 3.01±0.46 | 1.05±0.34 | 1.53±0.15 | 0.0099±0.0023 | 0.0139±0.0015 | −0.3±2.1 | −0.1±2.7 | 23 | 39 | |
7 | 2.1 | 3.1 | −0.44±0.26 | 0.73±0.17 | 0.59±0.11 | 0.98±0.17 | −0.006±0.0008 | 0.0326±0.0008 | −0.4±0.8 | −0.3±0.5 | 31 | 49 | |
8 | 0.9 | 1.0 | 3.76±0.63 | 3.86±0.87 | 2.11±0.30 | 2.24±0.32 | 0.0365±0.0006 | 0.0252±0.0151 | 0.6±2.1 | 0.6±1.6 | 13 | 26 | |
9 | 1.2 | 2.0 | 3.29±0.46 | 2.28±0.27 | 0.72±0.57 | 1.59±0.40 | 0.0472±0.0023 | 0.0070±0.0031 | −0.6±0.9 | 0.3±1.2 | 10 | 25 | |
Inhaled Air Mean±SEM | 1.2±0.1 | 2.0±0.2 | 2.0±0.8 | 2.4±0.5 | 1.0±0.3 | 1.35±0.27 | 0.0371±0.0100 | 0.026±0.006 | 1.1±1.3 | 0.4±0.4 | 18±2 | 32±3 | |
| |||||||||||||
10 | 1.5 | 1.7 | −0.93±0.55 | 2.52±0.59 | 0.32±0.16 | 1.62±0.29 | 0.0460±0.0018 | ND | −1.0±1.7 | −3.2±1.1 | 28 | 39 | |
11 | 1.1 | 1.7 | −3.26±0.62 | 3.29±0.62 | 1.07±0.14 | 1.63±0.19 | 0.1213±0.0023 | 0.0070±0.0018 | 2.1±1.6 | −0.3±1.1 | 24 | 30 | |
12 | 0.7 | 1.1 | 1.43±0.20 | 0.61±0.40 | 0.76±0.12 | 1.19±0.17 | 0.0393±0.0018 | 0.0460±0.0013 | 1.7±2.4 | 1.0±1.8 | 23 | 32 | |
13 | 0.9 | 0.9 | 4.52±0.95 | 4.77±0.64 | 1.97±0.19 | 1.72±0.24 | 0.0677±0.0014 | 0.0015±0.0022 | −1.0±1.3 | 0.3±2.3 | 31 | 43 | |
14 | 1.2 | 2.5 | 3.55±1.29 | 3.24±0.45 | 0.77±0.26 | 2.53±0.22 | 0.0520±0.0021 | 0.0601±0.0036 | −1.5±1.8 | −0.3±1.0 | 25 | 40 | |
15 | 1.1 | 0.9 | 7.94±0.80 | 2.22±0.47 | 1.40±0.33 | 1.68±0.20 | 0.0308±0.0017 | 0.0730±0.0013 | −3.3±1.3 | −2.4±1.6 | 28 | 36 | |
16 | 1.6 | 2.7 | 1.64±0.27 | 2.50±0.44 | 1.25±0.15 | 1.57±0.15 | 0.0310±0.0011 | 0.0136±0.0013 | −0.8±1.2 | −2.3±0.8 | 30 | 42 | |
17 | 1.7 | 2.6 | 2.60±0.60 | 3.43±0.57 | 1.03±0.23 | 3.00±0.56 | 0.0011±0.0016 | 0.0085±0.0008 | 5.4±1.4 | −3.3±0.9 | 28 | 48 | |
18 | 1.7 | 3.1 | 4.77±0.64 | 3.47±0.51 | 1.51±0.14 | 2.13±0.20 | 0.0069±0.0010 | 0.0161±0.0009 | −1.2±1.1 | −0.5±1.1 | 37 | 42 | |
Inhaled Oxygen Mean±SEM | 1.3±0.1 | 1.9±0.3 | 2.5±1.1 | 2.9±0.4 | 1.1±0.2 | 1.9±0.2 | 0.044±0.012 | 0.028±0.010 | 0.04±0.86 | −1.2±0.5 | 28±1 | 39±2 | |
| |||||||||||||
Overall Mean±SEM | 1.3±0.1 | 2.1±0.2 | 2.2±0.7 | 2.6±0.3 | 1.1±0.2 | 1.6±0.2 | 0.041±0.007 | 0.027±0.006 | 0.55±0.75 | −0.42±0.38 | 20±2 | 32±2 | |
P-valuea | 0.7093a | 0.7160a | 0.7351a | 0.4576a | 0.8241a | 0.1144a | 0.6570a | 0.8449a | 0.5155a | 0.0271a | 0.0006a | 0.0356a | |
P-valueb,c | 0.4235b, 0.5799 c | 0.9822b | 0.4242b | 0.7071b | 0.7353b | <0.0001 c | <0.0001 c |
Data values reported as mean ± standard error of the mean (SEM) from voxels averaged over two slices for BOLD, TOLD, and R2* and three slices for R1.
ND- missing values due to logistic issues.
– P-values for comparisons (two-sample t-tests) of each covariate for differences in inhaling air vs. oxygen.
– P-values for comparisons (two-sample t-tests) of each covariate for differences in pre1F- vs. pre2F controlled treatment groups (inhaling air vs. oxygen)
– P-values for comparisons (general linear analysis) in differences of initial, VDT, or VQT tumor volumes vs. control tumor volumes (not shown in table).
VDT: time the tumors reached 2 times the initial irradiated tumor volume; VQT: time the tumors reached 4 times the initial irradiated tumor volume
BOLD: blood-oxygenation level dependent; TOLD: tissue-oxygenation level dependent; ΔR1: intrinsic longitudinal relaxation rate; ΔR2*: apparent transverse relaxation rate
pre1F- measurements before the first irradiation
pre2F- measurements six days after the first irradiation and before the second irradiation