Table 2.

Risk factors predictive of imminent risk for fracture (OR > 1) at any fracture site

Predictor	12 months prefracture OR (95 % CI)	P value	24 months prefracture OR (95 % CI)	P value
Demographic and general health characteristics
History of falls	6.67 (6.03–7.37)	<0.0001	4.43 (4.09–4.80)	<0.0001
Every additional decade after age 50 years	2.00 (1.98–2.03)	<0.0001	1.97 (1.94–2.00)	<0.0001
Comorbidities
CNS disease	1.41 (1.30–1.52)	<0.0001	1.34 (1.25–1.43)	<0.0001
Psychoses	1.37 (1.26–1.48)	<0.0001	1.34 (1.25–1.44)	<0.0001
Alzheimer’s disease	1.35 (1.22–1.50)	<0.0001	1.25 (1.14–1.37)	<0.0001
General health status measures
DCIa
≥4	1.46 (1.35–1.59)	<0.0001	1.49 (1.38–1.62)	<0.0001
3	1.40 (1.31–1.50)	<0.0001	1.42 (1.32–1.52)	<0.0001
2	1.26 (1.19–1.32)	<0.0001	1.29 (1.22–1.36)	<0.0001
1	1.16 (1.12–1.20)	<0.0001	1.17 (1.13–1.22)	<0.0001
Concomitant medications
Narcotics	2.11 (2.05–2.18)	<0.0001	1.85 (1.79–1.92)	<0.0001
Antidepressants—SSRIs	1.47 (1.41–1.52)	<0.0001	1.41 (1.36–1.46)	<0.0001
Muscle relaxants	1.40 (1.34–1.47)	<0.0001	1.29 (1.25–1.35)	<0.0001
Tranquilizers	1.29 (1.18–1.40)	<0.0001	1.24 (1.15–1.34)	<0.0001
Antidepressants—other	1.27 (1.21–1.33)	<0.0001	1.22 (1.16–1.27)	<0.0001
Anti-Parkinson	1.24 (1.15–1.35)	<0.0001	1.20 (1.11–1.29)	<0.0001
Antidepressants—tricyclics	1.09 (1.02–1.17)	0.0119	–	NS
Sedatives and sleep aids, excluding benzodiazepines	1.05 (1.00–1.11)	0.0376	1.08 (1.03–1.12)	0.0010
Mobility/frailty
Wheelchair use	1.79 (1.61–2.00)	<0.0001	1.80 (1.64–1.97)	<0.0001
Mobility impairment	1.46 (1.41–1.51)	<0.0001	1.39 (1.34–1.43)	<0.0001
Home healthcare	1.24 (1.16–1.34)	<0.0001	1.20 (1.13–1.28)	<0.0001
Nursing home	1.19 (1.12–1.28)	<0.0001	1.19 (1.13–1.26)	<0.0001

Risk factors with OR > 1 and significant (P < 0.05) included on table

CNS central nervous system, DCI Deyo-Charlson Comorbidity Index, NS nonsignificant, OR odds ratio, SSRI selective serotonin reuptake inhibitor

^aReference group: 0