Fig 4.

Liver microsomal stability of simvastatin lactone at 3 different pH levels. (A) Microsomal stability of simvastatin lactone as a function of time at different pH levels; (B) concentration-time profiles of simvastatin hydroxy acid form detected in liver microsomal stability reaction mixtures at 3 different pH levels. Results are expressed as mean ± standard deviation, (n = 3). Solid line denotes exponential regression of samples at pH 6.8; dashed line denotes exponential regression of samples at pH 7.4; whereas dotted line denotes exponential regression samples at pH 7.8.