Supplementary Table II.

Optimized LC MS/MS parameters used for analysis of statins

Compound	Precursor type	Parent ion m/z	Daughter ion m/z	Capillary voltage (kV)	Cone voltage (V)	Collision energy (eV)
SVL	[M+H]+	419.29	119.17	4.00	35	23
SVA	[M-H]−	435.49	319.43	3.20	45	14
PVL	[M+H]+	407.46	183.22	3.5	35	18
PVA	[M-H]−	423.23	321.37	3.2	35	16
LOV-L	[M+Na]+	427.15	325.36	4.00	35	23
LOV-A	[M-H]−	421.08	319.54	3.20	45	14

Abbreviations: LOV-A, lovastatin acid; LOV-L, lovastatin lactone; PVA, pravastatin hydroxy acid; PVL, pravastatin lactone; SVA, simvastatin hydroxy acid; SVL, simvastatin lactone.