Supplementary Table VIII.
Extraction recovery (%) of statins from human plasma, PBS, and DMEM samples
| Statins | Quality control levels | % Of statin recovered (mean ± SD, n = 6) |
||
|---|---|---|---|---|
| Plasma samples | PBS samples | DMEM samples | ||
| Simvastatin lactone | LQC | 80.75 ± 14.89 | 96.80 ± 6.04 | 94.48 ± 2.76 |
| MQC | 89.14 ± 7.40 | 96.28 ± 11.12 | 93.41 ± 2.94 | |
| HQC | 87.52 ± 13.50 | 92.94 ± 12.23 | 82.68 ± 7.48 | |
| Simvastatin hydroxy acid | LQC | 87.61 ± 16.11 | 90.15 ± 12.3 | 94.43 ± 3.77 |
| MQC | 84.61 ± 15.74 | 86.66 ± 14.98 | 70.82 ± 6.81 | |
| HQC | 88.13 ± 10.66 | 95.57 ± 3.32 | 83.40 ± 20.31 | |
| Pravastatin lactone | LQC | 76.53 ± 16.27 | 88.52 ± 9.11 | 78.81 ± 26.59 |
| MQC | 85.40 ± 16.22 | 86.55 ± 3.98 | 91.46 ± 13.07 | |
| HQC | 80.58 ± 8.47 | 88.43 ± 8.37 | 90.11 ± 12.15 | |
| Pravastatin hydroxy acid | LQC | 78.56 ± 7.80 | 77.32 ± 5.06 | 77.83 ± 11.90 |
| MQC | 83.08 ± 13.27 | 81.71 ± 26.71 | 78.73 ± 5.33 | |
| HQC | 81.95 ± 15.63 | 88.73 ± 31.67 | 88.48 ± 5.36 | |
Abbreviations:DMEM, Dulbecco's modified eagle medium; HQC, high concentration quality control; LLOQ, lower limit of quantification; LQC, low concentration quality control; MQC, medium concentration quality control; PBS, phosphate buffer saline.