Figure S1.

NPC Composition, Related to Figure 1

(A) Cryo-EM structure of the human NPC (von Appen et al., 2015) together with nuclear membranes (gray).

(A′) Schematic representation of NPC sub-complexes. Transmembrane Nups, inner ring- and Y-complex are symmetric while distinct sub-complexes create asymmetry across the nuclear envelope.

(B) Constituents of the Drosophila NPC. Nups that were used in imaging experiments in this study are highlighted in white (Y-complex Nups), red (FG-Nups) and blue (Mtor).

(C) Nuclear envelope (NE), endoplasmic reticulum (ER) and annulate lamellae (AL) constitute one membrane continuum and share a common lumen.