Figure 2.
Representation of Cancer Functional Events in Cancer Cell Lines
(A) First bar chart: the percentage coverage of cancer functional events (CFEs) in the pan-cancer dataset occurring in at least one cell line. Coverage for each class of CFEs individually and when combined is shown. Second bar chart: the median coverage by cancer type of frequently occurring (>5% of tumor samples) cancer-specific CFEs in at least one cell line. The solid line indicates coverage of CFEs occurring in >2 cell lines. Third bar chart: coverage in each cancer type of frequently occurring cancer genes (CGs). Missing cancer genes are grouped by the level of evidence supporting their classification as a cancer gene. The number of cell lines for each cancer-type and the full name of each cancer-type and associated acronym are shown.
(B) Matrix of Pearson correlations of CFE frequency between cell lines and patient tumors for each cancer-type and class of CFEs. Box and whisker plots show the correlations of CFEs within the same (on-diagonal) and between different (off-diagonal) cancer-types.