Figure 6.

Mll-AF4 Expression Causes B Lymphomas

(A) Kaplan-Meier survival plot. The control curve includes the pooled data from littermates with a WT, VEC-Cre only, Vav-Cre only, and Mll-AF4+Cre-genotypes (^∗∗∗p < 0.001).

(B) Diseased mouse with a mesenteric tumor (black arrow) and an enlarged spleen (red arrow) is shown.

(C) H&E-stained section of a diseased liver shows malignant cell infiltration (arrow).

(D) Example shows splenomegaly with the enlarged spleen of an Mll-AF4-expressing mouse on the right and a control spleen on the left.

(E) Diseased spleens contain strong B and T cell components.

(F) Secondary mesenteric (black arrow) and bowl (red arrow) tumors following injection of diseased spleen cells into secondary recipients are shown.

(G–I) B and T cell components in the (G) mesenteric tumor, broken down into (H) donor and (I) recipient, are shown.

(J) Percentages of tumor cell populations that are derived from donor and recipient are shown.