Table 1.

Effects of lycopene and sodium valproate on TBARS and reduced glutathione levels in pentylenetetrazol-induced changes in the brain tissue

S. No.	Groups	TBARS (nmol MDA/mg protein)	Reduced glutathione (nmol/mg of protein)	P value
1	Normal Control	0.52±0.22	1.012±0.06
2	PTZ Control	3.49±0.36a	0.344±0.05a	0.009
3	SVP+PTZ	2.28±0.32b	0.899±0.07b	0.049
4	LYC2+SVP+PTZ	1.32±0.14c	0.923±0.07c	0.009
5	LYC4+SVP+PTZ	1.09±0.13c	0.952±0.07c	0.008

TBARS: Thiobarbituric acid reactive substance; PTZ: Pentylenetetrazol; SVP: Sodium valproate (200 mg/kg); LYC: Lycopene (2 and 4 mg/kg). Data are expressed as mean±SEM.

^aP<0.01 versus control;

^bP<0.05;

^cP<0.01 versus the PTZ control