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. Author manuscript; available in PMC: 2016 Jul 31.
Published in final edited form as: J Thorac Oncol. 2014 Jan;9(1):33–40. doi: 10.1097/JTO.0000000000000025

FIGURE 4.

FIGURE 4

The validation of the two miRNAs (miR-31 and miR-210) in a testing set of 64 lung cancer cases and 73 cancer-free smokers confirms their performance in improving the specificity of CT scan for lung cancer diagnosis. Combined use of miR-31 and miR-210 could create 64.1% sensitivity and 89.2% specificity in the testing set. Regular CT scan produces 93.8% sensitivity and 83.6% specificity. CT has a lower specificity and a higher sensitivity compared with the panel of the miRNA biomarkers (all p < 0.05). Combined analysis of the miRNAs and CT imaging has a higher specificity than does CT scan used alone (91.8% versus 83.6%; p < 0.05). miRNAs, microRNAs; CT, computed tomography.