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. 2016 Jul 30;35:124. doi: 10.1186/s13046-016-0393-0

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — ROC curves of serum miR-125b and miR-497 to discriminate glioblastomas from lower grade gliomas. a-b ROC curve plotted for diagnostic potential and discriminatory accuracy of serum miR-497 and miR-125b to distinguish GBM from G II/III gliomas. The corresponding AUC, sensitivity and specificity values are reported. c ROC curve for the combined miR-497/-125b panel by a dummy variable with value 1 for patients with decrement of both miRNAs and 0 for the other combinations. d The histogram represents the distribution, between GBM and lower grade gliomas (G II/III), of the patients with miRNA expression levels lower than the cut-off values (0,00083 for miR-497 and 0,00065 for miR-125b). p-values (* = p ≤ 0,05; ** = ≤ 0,01) were determined using the Fisher’s exact test