Table 2.
Immunohistochemical expression of leukotriene receptors
| Immunoreactive score (IRS) | ||||
|---|---|---|---|---|
| LTB4R | LTB4R2 | CYSLTR1 | CYSLTR2 | |
| CSE median (range) | 4 (0 - 8) | 4 (4 - 6) | 4 (4 - 8) | 4 (-) |
| NTSE median (range) | 8 (4 - 8) | 4 (0 - 4) | 4 (0 - 8) | 4 (-) |
| ESCC median (range) | 8 (4 - 12) | 8 (4 - 12) | 8 (4 - 12) | 8 (4 - 12) |
| NTSE/CSE, p-value | 0.034 | 0.588 | 1 | 1 |
| ESCC/CSE, p-value | 0.0016 | 0.016 | 0.252 | 0.016 |
| ESCC/NTSE, p-value | 1 | 0.0059 | 0.047 | 0.0234 |
IRS of all receptors are shown in the upper part of the table. Medians of IRS and corresponding range of staining intensities are shown for each group. In the lower part of the table comparisons between the different histological groups are shown. For statistical analysis, Wilcoxon signed-rank test was applied on groups of cancer patient whereas Mann-Whitney U test was used for inter-individual comparisons. All p-values were multiplied by k = 12 (Bonferroni correction) and considered significant when <0.05. Significant changes are displayed in bold letters. ESCC esophageal squamous cell cancer, NTSE non-transformed squamous epithelium of cancer patients, CSE control squamous epithelium; p < 0.05 (Wilcoxon signed-rank test, Mann-Whitney U test, Bonferroni correction k = 12)